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At last, we simply cannot rule out substitute hypotheses. Such as, stress and anxiety and sleep Diseases, two of the principle indications for benzodiazepines, may be related to early β amyloid lesions in brain,forty two 58 and persistent mid-lifetime stress might be associated with a higher risk of dementia in more mature folks.

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The RAMQ databases does not incorporate info on socioeconomic status, education degree, smoking behavior, or Alcoholic beverages use. Smoking and Liquor usage are regarded to become connected with benzodiazepine use although not a priori with Alzheimer sort dementia, even though Continual wine intake has long been claimed to become a protective issue.51 The outcome of not adjusting for these things was very likely to be conservative as benzodiazepine use is thought to be increased in frequent wine and alcohol buyers.

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Benzodiazepine use was assessed with dispensation claims recorded in the RAMQ databases. We considered all benzodiazepines A part of the RAMQ list of reimbursed drugs over the study interval (table one⇓).

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In regard to a attainable delay in recording a analysis of Alzheimer’s sickness, one need to Be aware that pushing back the index day by just one yr within the sensitivity analysis didn't alter the outcome.

Heterogeneity in between database certain odds ratios was assessed by Cochran’s Q (and corresponding P value) and Higgins’ I2 statistics. No=quantity of summarised databases

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